This is especially true for genetic designs expressed heterologously and when a system is engineered first in one organism (e.g., ), then moved to a different host (e.g., ). These properties become relevant as genetic designs become more complex, with multiple promoters, CDSs, etc. A visual representation of genetic sequence elements and their arrangement can quickly communicate adjacency, contiguity, repetition, and uniqueness.
This has increased the need for consistent terminology and representations of genetic designs. This effort helped unify annotation efforts during the rise of high-throughput genome sequencing in the last decade.Īcross that same decade, synthetic biology has advanced capabilities for forward engineering of complex genetic systems with multiple sequence features. To address such concerns, the Sequence Ontology maintains a standard set of terms for describing different genetic features. A protein-coding DNA sequence might be called a coding sequence (CDS), an open reading frame, an exon, or simply a gene, depending on the organism and method of study. By the 1970s, molecular biologists had already developed many variations in the language used to describe functional regions of DNA, or genetic sequence features, with different terms used to describe similar features in different organisms.
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